Therapeutic targeting of replicative immortality
نویسندگان
چکیده
منابع مشابه
Therapeutic targeting of replicative immortality
One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuel increasingly autonomous growth, invasiveness, and therapeutic resistance. Innate cellular mechanisms have evolved to regulate replicative potential as a hedge against malignant progression. When activated in t...
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ژورنال
عنوان ژورنال: Seminars in Cancer Biology
سال: 2015
ISSN: 1044-579X
DOI: 10.1016/j.semcancer.2015.03.007